In Tales of Popolon you play as Popolon, an ancient Greek hero tasked with a mission from Thanatos. He must discover who is trapping souls of people in an evil fortress built at the base of Mount Olympus and stopping them!

The game is designed to be played on MSX1 computers with at least 16KB of RAM, but if the game detects that you are running on a Panasonic MSX2+, then turbo will be activated to get 50% more speed. Also, if the game detects you are running it on a Turbo R, the game will switch to the R800 CPU to also take advantage from the extra speed (you can press "R" while playing the game to switch between the different CPU modes in a Turbo R).